{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:10:08Z","timestamp":1782940208477,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Porocarcinoma is the malignant counterpart of poroma, a benign tumor derived from the eccrine or apocrine units. In contrast to poroma, porocarcinoma is rare and its diagnosis may be challenging. Recent work has identified <jats:italic>YAP1<\/jats:italic>\u2010associated gene fusions in most poromas, and a subset of porocarcinomas. These included <jats:italic>YAP1\u2010MAML2<\/jats:italic> and <jats:italic>YAP1\u2010NUTM1<\/jats:italic>, the latter being enriched in porocarcinomas over poromas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied YAP1 C\u2010terminus and NUT immunohistochemistry in a cohort of 12 porocarcinomas, 10 poromas, 10 squamous cell carcinomas, and 6 hidradenocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven of 12 (58%) porocarcinomas showed loss of YAP1 C\u2010terminus expression, consistent with a <jats:italic>YAP1<\/jats:italic> fusion. Of these seven, five showed NUT positivity, implying the presence of the <jats:italic>YAP1\u2010NUTM1<\/jats:italic> fusion. One of 12 (8%) cases showed NUT positivity, but retention of <jats:italic>YAP1 C<\/jats:italic>\u2010terminus expression, consistent with a non\u2010<jats:italic>YAP1 NUT<\/jats:italic>\u2010associated fusion. Eight of 10 (80%) poromas showed loss of YAP1 C\u2010terminus expression and negative NUT staining, consistent with non\u2010<jats:italic>NUT YAP1<\/jats:italic> fusions. All squamous cell carcinomas and hidradenocarcinomas retained <jats:italic>YAP1 C<\/jats:italic>\u2010terminus expression and were negative for NUT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>YAP1 C\u2010terminus and NUT immunohistochemistry may be helpful in the diagnosis of porocarcinoma, with the combination of YAP1 C\u2010terminus loss and NUT positivity being particularly informative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13924","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T08:22:35Z","timestamp":1606033355000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Utility of <scp>YAP1<\/scp> and NUT immunohistochemistry in the diagnosis of porocarcinoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-6257","authenticated-orcid":false,"given":"Eleanor","family":"Russell\u2010Goldman","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts 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