{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T12:37:40Z","timestamp":1759667860108,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) is associated with an increased risk of a second malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective clinicopathologic review of 12 patients with CLL\/SLL who developed a second lymphoma in the skin. Demographic data, clinical information, and histopathology from 31 biopsies were recorded. Cases of secondary cutaneous involvement by CLL\/SLL (leukemia cutis) and non\u2010primary cutaneous lymphomas were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A wide variety of primary cutaneous lymphomas was identified, including classic mycosis fungoides (3), cutaneous marginal zone lymphoma (2), primary cutaneous peripheral T\u2010cell lymphoma unspecified (2), folliculotropic mycosis fungoides (1), S\u00e9zary syndrome (1), cutaneous gamma\u2010delta T\u2010cell lymphoma (1), cutaneous CD8+ aggressive epidermotropic cytotoxic T\u2010cell lymphoma (1), and cutaneous anaplastic large cell lymphoma (1). A male predominance was observed, and the average age was 74.1\u2009years. In all patients, CLL\/SLL predated the development of the second lymphoma, which was aggressive in the majority of cases (58%). Aggressive cytotoxic T\u2010cell lymphomas, generally rare neoplasms, were relatively common (30%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CLL\/SLL patients may develop a second lymphoma in the skin, which may be aggressive. Atypical cutaneous lymphoid infiltrates in this patient population should not be assumed to represent secondary CLL\/SLL involvement and require thorough immunohistochemical analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13956","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T03:26:43Z","timestamp":1610508403000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary cutaneous lymphomas in patients with chronic lymphocytic leukemia\/small lymphocytic lymphoma (<scp>CLL<\/scp>\/<scp>SLL<\/scp>): A series of 12 cases"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-8774","authenticated-orcid":false,"given":"Yi Ariel","family":"Liu","sequence":"first","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Finn","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Island Health  Victoria British Columbia Canada"},{"name":"Department of Laboratory Medicine and Pathology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-1900","authenticated-orcid":false,"given":"Antonio","family":"Subtil","sequence":"additional","affiliation":[{"name":"Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017","author":"Swerdlow SH","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331606"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"107","article-title":"Chronic lymphocytic leukemia in the young patient","volume":"25","author":"Lima M","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.022277"},{"issue":"10","key":"e_1_2_6_7_1","first-page":"1378","article-title":"Eosinophilic dermatosis of myeloproliferative disease: characterization of a unique eruption in patients with hematologic disorders","volume":"137","author":"Byrd JA","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/9781118492505","volume-title":"Skin Lymphoma. 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Evidence for multiple in vivo T cell clonal expansions","volume":"153","author":"Farace F","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPHXO5UGW2OELA"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31821528bc"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13956","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:30:45Z","timestamp":1693560645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,23]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/cup.13956"],"URL":"https:\/\/doi.org\/10.1111\/cup.13956","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2021,1,23]]},"assertion":[{"value":"2020-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}