{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:44:12Z","timestamp":1770234252083,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In mycosis fungoides (MF), cutaneous granuloma formation is unusual. Furthermore, MF showing interstitial granuloma, a rare type, after combination therapy with interferon\u2010gamma (IFN\u2010\u03b3) and narrowband UVB (nbUVB) has not been previously reported. A 77\u2010year\u2010old man was referred to our hospital with a 2\u2010month history of erythroderma. Biopsied specimens revealed infiltration of atypical lymphocytes and eosinophils. A diagnosis of an erythrodermic variant of MF was made. He was treated with combination therapy of IFN\u2010\u03b3 and nbUVB. After the therapy, papules newly appeared and a histopathological specimen revealed interstitial granuloma. There were several CXCR3\u2010positive cells around the granuloma. We speculated that the combination therapy made T\u2010helper 1 cells migrate to the cutaneous lesion and resulted in the granuloma formation. Furthermore, judging from the disappearance of elastic fibers around the interstitial granuloma, we considered that IFN\u2010\u03b3 may induce the infiltration of histiocytes interstitially after damage of elastic fibers caused by nbUVB therapy, and both IFN\u2010\u03b3 and nbUVB may thus play an important role in the histogenesis. Not only histopathology but also immunological observations are needed to elucidate the mechanisms underlying the development of different types of granuloma in MF.<\/jats:p>","DOI":"10.1111\/cup.13960","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:17:53Z","timestamp":1610734673000},"page":"689-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interstitial granuloma after interferon\u2010gamma and narrowband<scp>UVB<\/scp>therapy in a patient with mycosis fungoides: Immunological and histopathological considerations"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-6291","authenticated-orcid":false,"given":"Hiroyuki","family":"Goto","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sugita","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.02.024"},{"issue":"3","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1684\/ejd.2019.3544","article-title":"Granuloma formation clinically presenting as erythroderma in a patient with peripheral T\u2010cell lymphoma","volume":"29","author":"Goto H","year":"2019","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80375-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050614"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02834.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0788"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00847"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14981"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12305"},{"issue":"1","key":"e_1_2_6_11_1","first-page":"38","article-title":"Long\u2010term effect of PUVA versus NB\u2010UVB on the skin: a comparative histopathological study","volume":"3","author":"Salem SAMFN","year":"2006","journal-title":"J Egypt Wom Dermatol Soc"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.06.010"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13960","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:46:44Z","timestamp":1697575604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,24]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/cup.13960"],"URL":"https:\/\/doi.org\/10.1111\/cup.13960","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,24]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}