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We present two cases of clinically different cutaneous toxicities on two patients with hematologic neoplasia. They were treated with different drugs and in both cases medications shared inhibition of PI3K as mechanism of action. The skin biopsy specimen showed endothelial cell atypia with large nuclei and mitotic figures. To the best of our knowledge, no other cases with these striking histopathologic findings have been reported with PI3K inhibitors or other anticancer targeted therapy.<\/jats:p>","DOI":"10.1111\/cup.13981","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T03:21:03Z","timestamp":1613100063000},"page":"789-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous eruption with reactive endothelial atypia due to emerging targeted cancer therapies: Report of two cases with clinico\u2010pathologic correlation"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-1282","authenticated-orcid":false,"given":"Cristina","family":"Moya\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid 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