{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:16:24Z","timestamp":1778498184478,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy. Oncologic drivers of ocular sebaceous carcinoma are incompletely understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective search of our pathology archives for OA sebaceous carcinoma identified 18 primary resection specimens. Immunohistochemistry for p16 and ZEB1 and RNA in\u2009situ hybridization for high\u2010risk human papillomavirus (HPV) subtypes were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010risk HPV was demonstrated in 2\/11 (18%) cases. p16 overexpression was observed in 10\/11 (91%). No association between gender, age at presentation, tumor location, intraepithelial spread, tumor size, and T\u2009stage was observed between HPV\u2010driven and nonviral cases. High expression of ZEB1 was observed in the intraepithelial component of 4\/14 (28%) cases and in the subepithelial component of 1\/13 (7%) cases. ZEB1 overexpression was not associated with HPV status, T stage, or tumor size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As previously described by others, our findings suggest that a subset of OA sebaceous carcinomas may arise via an HPV\u2010dependent pathway. However, unlike high\u2010risk HPV\u2010driven carcinomas of the oropharynx, we did not identify an association between HPV\u2010status and prognostic features. Furthermore, p16 expression was not a useful surrogate marker for HPV\u2010driven disease. ZEB1 overexpression is not associated with HPV in our cohort of ocular sebaceous carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13987","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T10:47:05Z","timestamp":1616323625000},"page":"1027-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>High\u2010risk<\/scp> human papillomavirus and <scp>ZEB1<\/scp> in ocular adnexal sebaceous carcinoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-9655","authenticated-orcid":false,"given":"Robert F.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Dermatology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhai R.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University 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