{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:59:26Z","timestamp":1781294366008,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sarcomatoid dedifferentiated melanoma (SDDM) is a recently recognized subtype of melanoma that stains diffusely for CD10 and lacks the expression of the usual melanocytic markers including S100, SOX10, MITF, and Melan A. Advances in next\u2010generation DNA sequencing technology have facilitated the increased recognition of this rare, aggressive spindle cell melanoma. Herein, a case of relatively early lesion of SDDM arising in association with melanoma in situ is highlighted. A 72\u2010year\u2010old man with a history of previously treated melanoma in situ on the face five\u2009years prior presented with a new rapidly growing lesion within the scar of the treated site. A shave biopsy of the lesion revealed a centrally located 1.8\u2010mm deep, poorly differentiated spindle cell neoplasm in association with an adjacent recurrent melanoma in situ. The spindle cell component stained diffusely for CD10, but failed to stain for S100, SOX10, and Melan\u2010A while the melanoma in situ expressed all three melanocytic markers. Next\u2010generation DNA sequencing assay revealed mutations in <jats:italic>NF1, CDKN2A, TP53,<\/jats:italic> and <jats:italic>TSC1<\/jats:italic>. A diagnosis of stage 2B SDDM arising in association with melanoma in situ was established based on the clinical context and genomic assay results.<\/jats:p>","DOI":"10.1111\/cup.14003","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T14:59:32Z","timestamp":1615042772000},"page":"943-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evolution of a melanoma in situ to a sarcomatoid dedifferentiated melanoma"],"prefix":"10.1111","volume":"48","author":[{"given":"Jina","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Temple University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2719","authenticated-orcid":false,"given":"Jason B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical College at Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000201"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000716"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000993"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13646"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001626"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200206000-00007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318236b17f"},{"issue":"11","key":"e_1_2_6_10_1","first-page":"13030","article-title":"Pleomorphic dermal sarcoma in a man with HIV: report with next\u2010generation sequencing analysis and review of the atypical fibroxanthoma\/pleomorphic dermal sarcoma spectrum","volume":"25","author":"Chen SX","year":"2019","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7845"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20127"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.06.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.146"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.142"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T04:39:08Z","timestamp":1693370348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/cup.14003"],"URL":"https:\/\/doi.org\/10.1111\/cup.14003","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}