{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:33:01Z","timestamp":1789237981763,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adnexal skin tumors are diagnostically challenging with few known molecular signatures. Recently, however, <jats:italic>YAP1\u2010MAML2<\/jats:italic> and <jats:italic>YAP1\u2010NUTM1<\/jats:italic> fusions were identified in poroid adnexal skin tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, we subjected eight poroid adnexal skin tumors (three poromas and five porocarcinomas) to fusion gene analysis by whole transcriptome sequencing and next\u2010generation DNA sequencing analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>YAP1<\/jats:italic> fusions were identified in six cases. <jats:italic>YAP1\u2010NUTM1<\/jats:italic> fusions were identified in two poromas and three porocarcinomas. A single case of porocarcinoma harbored a <jats:italic>YAP1\u2010MAML2<\/jats:italic> fusion. Two cases were negative for gene fusion. All cases that harbored <jats:italic>YAP1\u2010NUTM1<\/jats:italic> fusions showed nuclear protein in testis (NUT) expression by immunohistochemistry, with NUT being negative in the <jats:italic>YAP1\u2010MAML2<\/jats:italic>\u2010positive case. In this case series, we provide a detailed histopathologic description of six <jats:italic>YAP1<\/jats:italic>\u2010fused poroid skin tumors, which we show harbor reproducible histopathologic features, to include broad, bulbous tumor tongues with admixtures of basaloid, poroid cells punctuated by squamatized cuticles and ductules, with uniform tumor nuclei featuring frequent grooves and pseudonuclear inclusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Awareness of the characteristic histopathologic features of <jats:italic>YAP1<\/jats:italic>\u2010fused poroid adnexal skin tumor is a step toward a more reproducible classification of adnexal skin tumors as well as a step toward targeted therapy for metastatic and\/or unresectable examples of this poroid group of neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14008","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:24:09Z","timestamp":1615461849000},"page":"1139-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Poroid adnexal skin tumors with <scp><i>YAP1<\/i><\/scp> fusions exhibit similar histopathologic features: A series of six <i><scp>YAP1<\/scp>\u2010<\/i>rearranged adnexal skin tumors"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-7539","authenticated-orcid":false,"given":"Carlos","family":"Prieto\u2010Granada","sequence":"first","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Morlote","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at 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