{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:07:25Z","timestamp":1780610845713,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Perineuriomatous nevi are rare and diagnostically problematic. We report a series of eight perineuriomatous nevi to highlight the diagnostic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were retrospectively reviewed and characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 42.5\u2009years (range 25\u201064), with equal sex distribution. Lesions occurred on the arm (n\u00a0=\u00a04), trunk (n\u00a0=\u00a02), and head\/neck (n\u00a0=\u00a02). Median size was 7.5\u2009mm (range 5\u201012\u2009mm). Clinical differential diagnoses included atypical nevus (3), blue nevus (1), neurofibroma (1), and dermatofibroma (1). Lesions were circumscribed, dome\u2010shaped (5\/8), and biphasic (8\/8) with nested epithelioid cells and wavy spindled cells arranged in whorled fascicles in a myxocollagenous stroma. When present, junctional growth was lentiginous (4\/8). No cases displayed pleomorphism or mitotic figures. The perineuriomatous component stained positively for epithelial membrane antigen (8\/8 focal to diffuse) and CD34 (4\/5 focal to diffuse). SOX10 and S100 protein stained all nevoid cells and in some cases a subset of intermingled spindled cells in perineuriomatous areas, where other melanocytic markers were negative. p16 protein expression was uniformly retained (3\/3), and p53 negative (0\/2). Nevoid cells in most lesions were positive for BRAFV600E (5\/7). Ki67 was mildly elevated (~5%) in 3\/3 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recognizing the histopathologic and immunophenotypic features in these unusual nevi helps avoid overdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14014","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T10:57:17Z","timestamp":1616324237000},"page":"1223-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perineuriomatous nevi: A series of eight cases highlighting unifying pathologic features to avoid misdiagnosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-631X","authenticated-orcid":false,"given":"John L.","family":"McAfee","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio 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