{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:20:26Z","timestamp":1791991226384,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous follicle center lymphoma (PCFCL) is the most common cutaneous B\u2010cell lymphoma. The typical immunophenotype includes expression of both CD20 and BCL6, with the majority of cases lacking expression of CD10, BCL2, and the characteristic t(14;18)\/<jats:italic>IGH\u2010BCL2<\/jats:italic> rearrangement seen in systemic follicular lymphoma (FL). Plasmacytic differentiation (PD) is an uncommon finding in both systemic and cutaneous FLs and presents a diagnostic challenge when present, leading to the potential for misdiagnosis as marginal zone lymphoma (MZL). Limited reports have described light chain restriction in the plasma cell component of FLs with PD, and rare cases of PCFCL with PD have been described. While the <jats:italic>IGH\u2010BCL2<\/jats:italic> translocation has been identified in a subset of FLs with PD, the presence of the <jats:italic>BCL2<\/jats:italic> translocation in monotypic plasma cells of PCFCL has not been previously described to our knowledge. Here, we report a case of PCFCL with extensive PD in a 77\u2010year\u2010old woman that was favored to represent primary cutaneous MZL on an initial punch biopsy. Excisional biopsy, however, revealed that the atypical lymphocytes expressed CD10, BCL6, and BCL2, while the plasma cell component demonstrated light\u2010chain lambda restriction. FISH studies showed the presence of an <jats:italic>IGH<\/jats:italic>\u2010<jats:italic>BCL2<\/jats:italic> translocation in both the lymphocytic and plasmacytic components.<\/jats:p>","DOI":"10.1111\/cup.14020","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T08:34:15Z","timestamp":1617179655000},"page":"969-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary cutaneous follicle center lymphoma with extensive plasmacytic differentiation and t(14;18) in both the lymphoid and plasma cell components"],"prefix":"10.1111","volume":"48","author":[{"given":"Justin T.","family":"Kelley","sequence":"first","affiliation":[{"name":"Department of Pathology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-6591","authenticated-orcid":false,"given":"Alexandra C.","family":"Hristov","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dermatology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-466X","authenticated-orcid":false,"given":"Scott C.","family":"Bresler","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dermatology Michigan Medicine, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6396"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.05.009"},{"key":"e_1_2_7_5_1","first-page":"652","volume-title":"Diagnostic Pathology: Neoplastic Dermatopathology","author":"Auerbach A","year":"2017"},{"key":"e_1_2_7_6_1","first-page":"456","volume-title":"Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas","author":"Medeiros LJ","year":"2018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13399"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00015"},{"key":"e_1_2_7_9_1","article-title":"Cutaneous follicle center lymphomas with plasmacytic differentiation","author":"Skala 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