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Immunophenotypic switch (IS) is a phenomenon that occurs during lymphoma progression and is defined by an alteration in the immunophenotypic expression of a tumor with retention of its genotypic signature. This has been well\u2010recognized in hematopoietic neoplasms; however, it has been rarely reported in CTCL and its clinical implications are not well understood. We present the clinical, histopathologic, immunophenotypic, and genetic findings of three cases of CTCL that demonstrated IS post treatment with variable outcomes. We add our cases to the small number previously reported to increase awareness of this phenomenon and its diagnostic challenge.<\/jats:p>","DOI":"10.1111\/cup.14026","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T04:42:07Z","timestamp":1618548127000},"page":"986-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Immunophenotypic switch in cutaneous T\u2010cell lymphoma: A series of three cases and review of the literature"],"prefix":"10.1111","volume":"48","author":[{"given":"Carole","family":"Bitar","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Hile","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of 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