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Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, a 31\u2010year\u2010old women, had a subcutaneous mass in the right axilla. The resected specimen contained a circumscribed mass, with proliferating tumor cells that exhibited prominent nucleoli. They exhibited glandular and papillary growth patterns and there were amphophilic secretions in the glands. Immunohistochemically, the tumor cells were positive for mammaglobin and S100. The tumor was surrounded by sweat glands and there was no mammary glandular tissue, suggesting that it was derived from axillary sweat glands. Accordingly, we made a diagnosis of secretory carcinoma of the skin. Four years after the operation, there were metastases in both lungs. The resected specimen revealed a tumor identical to that of the original skin tumor. Next\u2010generation sequencing\u2010based multiplex gene assay performed on the metastatic tissue revealed an <jats:italic>ETV6\u2010NTRK3<\/jats:italic> fusion gene. This is a rare case report of secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs.<\/jats:p>","DOI":"10.1111\/cup.14028","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T04:37:45Z","timestamp":1619066265000},"page":"1069-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs: A case report"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-9221","authenticated-orcid":false,"given":"Kohei","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Pathology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Hospital  Okayama 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