{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:46:40Z","timestamp":1791586000352,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fusions of\n                    <jats:italic>ALK<\/jats:italic>\n                    ,\n                    <jats:italic>ROS1<\/jats:italic>\n                    ,\n                    <jats:italic>NTRK1<\/jats:italic>\n                    ,\n                    <jats:italic>NTRK3<\/jats:italic>\n                    ,\n                    <jats:italic>RET<\/jats:italic>\n                    ,\n                    <jats:italic>MET<\/jats:italic>\n                    ,\n                    <jats:italic>MERTK<\/jats:italic>\n                    ,\n                    <jats:italic>FGFR1<\/jats:italic>\n                    ,\n                    <jats:italic>ERBB4<\/jats:italic>\n                    ,\n                    <jats:italic>LCK<\/jats:italic>\n                    ,\n                    <jats:italic>BRAF<\/jats:italic>\n                    ,\n                    <jats:italic>MAP3K8<\/jats:italic>\n                    ,\n                    <jats:italic>MAP3K3<\/jats:italic>\n                    , and\n                    <jats:italic>PRKDC<\/jats:italic>\n                    and mutation of\n                    <jats:italic>HRAS<\/jats:italic>\n                    have so far been discovered as the genetic alterations associated with the pathogenesis of Spitz neoplasms. This report presents the first case of\n                    <jats:italic>NTRK2<\/jats:italic>\n                    \u2010rearranged Spitz\/Reed nevus. The patient was a 39\u2010year\u2010old male with a pigmented macule rapidly growing on his shoulder. Histopathologically, the lesion was a junctional melanocytic nevus composed of large nests of spindled melanocytes with abundant eosinophilic cytoplasm associated with a hyperplastic epidermis. These findings fulfilled the diagnostic criteria of a pigmented spindle cell nevus of Reed (variant of Spitz nevus). Immunohistochemistry for pan\u2010Trk revealed diffuse cytoplasmic positivity in the tumor cells, but immunoexpression of ALK, ROS1, and BRAF V600E was not seen. A novel, in\u2010frame,\n                    <jats:italic>TFG<\/jats:italic>\n                    \u2010\n                    <jats:italic>NTRK2<\/jats:italic>\n                    fusion was identified by RNA sequencing. This case report expands the list of genetic alterations in Spitz neoplasms and the spectrum of\n                    <jats:italic>NTRK2<\/jats:italic>\n                    \u2010rearranged tumors.\n                  <\/jats:p>","DOI":"10.1111\/cup.14062","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:05:15Z","timestamp":1620821115000},"page":"1193-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Spitz nevus with a novel\n                    <scp>\n                      <i>TFG\u2010NTRK2<\/i>\n                    <\/scp>\n                    fusion: The first case report of\n                    <scp>\n                      <i>NTRK2<\/i>\n                    <\/scp>\n                    \u2010rearranged Spitz\/Reed nevus"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Diagnostic Pathology Osaka National Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"},{"name":"Universit\u00e9 de Lyon Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, 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