{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:29Z","timestamp":1791229469572,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Symmetric drug\u2010related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by gluteal\/anogenital erythema and symmetric involvement of other intertriginous location(s) without systemic signs. Clinicopathologic characterization has been limited to case reports and small series. We describe 19 new cases and review the literature to better define the clinical and histopathologic spectrum of SDRIFE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pathology archives were searched for \u201cSDRIFE\u201d and \u201cbaboon syndrome.\u201d Cases meeting clinical criteria were included. Clinical and histopathologic features were recorded. Previous reports of SDRIFE with histopathologic descriptions were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen new cases were included, over half triggered by antibiotics. Six new causative medications were identified. Median onset was 7\u2009days. Typical lesions were erythematous plaques or papules with or without scale. The most common histopathologic finding was superficial perivascular lymphocytic infiltrate followed by dermal eosinophils, spongiosis, and orthokeratosis. Basal vacuolization and apoptotic keratinocytes were less common. Interstitial histiocytes were present in almost half of our cases. Other findings included atypical lymphocytes and \u201cflame figure.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appreciation of the range of inciting medications and clinicopathologic features in SDRIFE will improve recognition of this condition. Although many histopathologic features overlap with other common dermatitides, biopsy may assist in excluding key clinical mimics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14090","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:48:32Z","timestamp":1624438112000},"page":"1471-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Symmetric drug\u2010related intertriginous and flexural exanthema: Clinicopathologic study of 19 cases and review of literature"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-1861","authenticated-orcid":false,"given":"Andrew M.","family":"Schuler","sequence":"first","affiliation":[{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Chaudet","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-466X","authenticated-orcid":false,"given":"Scott C.","family":"Bresler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kroshinsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalynn M.","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-1266","authenticated-orcid":false,"given":"May P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pathology, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00445.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13084"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201977"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2015.1190"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001722"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167829"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2015.03.007"},{"issue":"7","key":"e_1_2_7_10_1","first-page":"466","article-title":"Baboon syndrome\u201d. 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