{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:27:51Z","timestamp":1760909271220,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Talimogene laherparepvec (TVEC) is a genetically modified herpes simplex virus\u20101 approved as an intralesional oncolytic immunotherapy for the treatment of advanced melanoma. Cutaneous reactions at the site of injection may mimic recurrent or progressive melanoma; histopathological findings have included chronic granulomatous dermatitis, neutrophilic dermatitis, lymphocytic dermatitis, and pigment incontinence. We report a 39\u2010year\u2010old male with metastatic stage IIIc melanoma treated with TVEC with clinical regression of melanoma lesions that later developed pink nodules at sites of prior injection. Histopathology demonstrated a nodular mononuclear infiltrate that stained strongly and diffusely with CD45 and CD20 with a surrounding rim of CD3\u2010positive T\u2010cells. Immunoglobulin gene rearrangement was negative for a clonal B\u2010cell population. To our knowledge, this is the first report of a pseudolymphomatous reaction mimicking recurrent melanoma after TVEC therapy.<\/jats:p>","DOI":"10.1111\/cup.14094","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T04:24:57Z","timestamp":1625027097000},"page":"1423-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Talimogene laherparepvec pseudolymphomatous reaction mimicking metastatic melanoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-8515","authenticated-orcid":false,"given":"Ania","family":"Henning","sequence":"first","affiliation":[{"name":"Summa Health  Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Agnese","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine G.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology The Ohio State University  Columbus Ohio USA"},{"name":"Department of Pathology The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.246"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13048"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13332"},{"issue":"6","key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/ddg.13820","article-title":"Rash after a single injection of T\u2010VEC","volume":"17","author":"Wagenknecht D","year":"2019","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6803-0"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000369"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5347"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13387"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0466"},{"volume-title":"AJCC Cancer Staging Manual","year":"2017","author":"Edge SB","key":"e_1_2_4_11_1"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.164437"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.11.003"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13953"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1906-8"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1922-8"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:35:43Z","timestamp":1693190143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/cup.14094"],"URL":"https:\/\/doi.org\/10.1111\/cup.14094","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"2021-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}