{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:28:52Z","timestamp":1789565332808,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous acral CD8+ T\u2010cell lymphoma (PCACTL) is currently a provisional entity defined as a rare cutaneous proliferation of atypical CD8+ lymphocytes that preferentially involves acral sites and has a good prognosis. We present a case of primary cutaneous CD8+ T\u2010cell lymphoma involving the eyelid of an adolescent male. The case shares features with PCACTL, including indolent clinical behavior and expression of CD68 in a Golgi\u2010associated dot\u2010like pattern; however, other features differ significantly from PCACTL as currently defined by the World Health Organization (WHO). These features include ulceration, expression of CD56, granzyme B, and perforin, and a high proliferative index. Given these discrepancies, our case is currently best classified as a CD8+ primary cutaneous peripheral T\u2010cell lymphoma, not otherwise specified. We review the differential diagnosis for this case and suggest expanding the definition of PCACTL.<\/jats:p>","DOI":"10.1111\/cup.14095","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T14:33:52Z","timestamp":1625409232000},"page":"1489-1492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Indolent <scp>CD8<\/scp>+ primary cutaneous T\u2010cell lymphoma involving the eyelid of an adolescent"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-0248","authenticated-orcid":false,"given":"Andrew N.","family":"Minzenmayer","sequence":"first","affiliation":[{"name":"Department of Dermatology Baylor Scott and White Central Texas  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirby","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Baylor Scott and White Central Texas  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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-7557","authenticated-orcid":false,"given":"Andrew","family":"Siref","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Central Texas  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"248","volume-title":"World Health Organization Classification of Tumours","author":"Berti 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