{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:47Z","timestamp":1747184207169,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hailey\u2010Hailey disease (HHD) is an uncommon hereditary and benign skin condition characterized by blisters and erosions on intertriginous areas. It is related to a mutation of the <jats:italic>ATP2C1<\/jats:italic> gene, which encodes a Ca<jats:sup>2+<\/jats:sup> pump. It is characterized by multiple foci of skin acantholysis in the epidermis, with dyskeratosis and suprabasilar clefting. Galectin\u20103 is a beta\u2010galactoside\u2010binding protein that has an essential role in cell\u2010to\u2010cell and cell\u2010to\u2010matrix adhesion. We assessed galectin\u20103 immunohistochemical expression in HHD to explore its impact on the pathogenesis of this hereditary blistering disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a retrospective study, seven specimens from seven patients diagnosed with HHD were stained with antibodies to galectin\u20103. We evaluated the nuclear and cytoplasmic expression of galectin\u20103, as well as the staining intensity around blisters and distant normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a significant decrease in cytoplasmic and nuclear expression of galectin\u20103 as well as stain intensity around blisters compared with distant normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the acantholysis process in HHD is related to abnormality in cadherin expression caused by altered Ca<jats:sup>2+<\/jats:sup> pump concentration, lower expression of galectin\u20103 may cause the extension of blisters by initiating cell\u2010to\u2010cell disassembly in the epidermis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14102","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T02:30:00Z","timestamp":1626489000000},"page":"29-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weak immunohistochemical expression of galectin\u20103 near blisters in Hailey\u2010Hailey disease"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2133-6174","authenticated-orcid":false,"given":"Maryam","family":"Aghighi","sequence":"first","affiliation":[{"name":"Department of Pathology Harbor\u2010UCLA Medical Center  Torrance California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8274","authenticated-orcid":false,"given":"Bruce R.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Rochester School of Medicine and 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