{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:02Z","timestamp":1778498462904,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH2020208"],"award-info":[{"award-number":["TYH2020208"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Merkel cell polyomavirus (MCPyV) has been studied in several malignant and nonmalignant tissues. However, only in Merkel cell carcinoma (MCC) has the connection to tumorigenesis been established. Previously, eccrine porocarcinoma samples were shown to express MCPyV in the majority of samples. We aimed to examine MCPyV in porocarcinoma and poroma samples using MCC as the reference material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 17 porocarcinoma and 50 poroma samples for the presence of MCPyV using LT antigen immunostaining and DNA detection methods. In addition, 180 MCC samples served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MCPyV LT antigen immunostaining was detected in 10% of poroma and 18% of porocarcinoma samples; on the other hand, it was present in 65% of MCC samples. MCPyV DNA was detected in only 10% of poroma and porocarcinoma samples compared with 96% of MCC samples. The viral DNA copy number in all MCPyV DNA\u2010positive MCCs was at least 25 times higher than that in porocarcinoma or poroma samples with the highest MCPyV DNA\u2010to\u2010<jats:italic>PTPRG<\/jats:italic> ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The low number of viral DNA copies in poroma and porocarcinoma samples, together with the negative LT expression of MCPyV DNA\u2010positive tumors, indicates that MCPyV is simply a passenger virus rather than an oncogenic driver of porocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14109","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T03:46:41Z","timestamp":1627357601000},"page":"49-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Merkel cell polyomavirus is a passenger virus in both poroma and porocarcinoma"],"prefix":"10.1111","volume":"49","author":[{"given":"Anna\u2010Stiina","family":"Meril\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Surgery The Central Hospital of Tavastia Proper  H\u00e4meenlinna Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-5509","authenticated-orcid":false,"given":"Harri","family":"Sihto","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-4829","authenticated-orcid":false,"given":"Virve","family":"Koljonen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001566"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"adv00363","article-title":"Malignant eccrine porocarcinoma in Finland during 2007 to 2017","volume":"101","author":"Merilainen AS","year":"2021","journal-title":"Acta Derm 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