{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:37:54Z","timestamp":1783024674102,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Expression of microRNA\u201021 (miR\u201021) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP\u20103), a highly potent inhibitor of the tumor necrosis factor alpha (TNF\u03b1) sheddase TACE (TNF\u03b1\u2010converting enzyme)\/ADAM17. We described the profile of miR\u201021 and TIMP\u20103 in paradoxical psoriasiform reactions induced by anti\u2010TNF\u03b1 drugs and in a control group to elucidate the pathogenesis of this reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an analytic, cross\u2010sectional, prospective, experimental case\u2010control study. We compared our findings with those of non\u2010induced psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 15 patients with a change of morphology (plaque to guttate psoriasis) and 10 patients with induced psoriasis (six palmoplantar pustulosis and four plaque psoriasis). Consecutive patients with different subtypes of non\u2010induced, non\u2010systemically treated psoriasis were included as a control group. We found that most cases with guttate psoriasis and with induced plaque psoriasis cases showed high expression of TIMP\u20103 expression and decreased or poorly increased levels of miR\u201021. The expression pattern was not homogeneous in the cases of induced palmoplantar pustulosis. These profiles differ from those of non\u2010induced psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that various pro\u2010inflammatory cytokine profiles are involved in the pathogenesis of paradoxical psoriasiform reactions and non\u2010induced psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14113","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T04:15:18Z","timestamp":1627532118000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression of microRNA\u201021 and TIMP\u20103 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-7845","authenticated-orcid":false,"given":"Raquel","family":"Navarro","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital 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