{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:04:02Z","timestamp":1789387442554,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated epidermal interleukin (IL)\u201036 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PDs) have not been thoroughly investigated for IL\u201036 expression. In this study, we assess the IL\u201036 staining pattern (IL36\u2010SP) in psoriasis variants and other PDs including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo (IMP), and syphilis (SY).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IL\u201036 immunostaining was performed on 307 cases of psoriasis and various PDs. IL36\u2010SP in the upper epidermis was graded on a scale of 0\u20104.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High IL36\u2010SP occurred in all variants of psoriasis, as well as in AGEP, PRP, PN, tinea, IMP, and LP (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). SY, PF, LSC, and MF showed a lower IL36\u2010SP (<jats:italic>P<\/jats:italic>\u00a0\u2264\u20090.05) compared with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All variants of psoriasis exhibit high IL36\u2010SP. IL\u201036 staining can assist in differentiating MF, PF, SY, and LSC from psoriasis, particularly MF and LSC, which have consistent low IL\u201036 expression. AGEP, PRP, tinea, IMP, PN, and LP exhibit high IL\u201036 expression similar to psoriasis, indicating Th17 activation in these diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14115","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:30:33Z","timestamp":1628065833000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin 36 expression in psoriasis variants and other dermatologic diseases with psoriasis\u2010like histopathologic features"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5736-2024","authenticated-orcid":false,"given":"Terese Monette","family":"Aquino","sequence":"first","affiliation":[{"name":"University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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