{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:30Z","timestamp":1759335630928,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/000587"],"award-info":[{"award-number":["PI18\/000587"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high\u2010risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of the non\u2010acantholytic (naCSCC) or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case\u2010control study with 50 aCSCCs and 50 naCSCCs. For each aCSCC, an naCSCC with similar high\u2010risk features to the aCSCC but with no acantholysis was selected. Prognosis between both groups was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 86\u2009years (SD 9.61). Sixty\u2010one patients were men. Thirty\u2010nine CSCCs were located in high\u2010risk head and neck areas. Twenty CSCCs exhibited a poor degree of differentiation, and 36 showed an infiltrative growth pattern. The tumor diameter was 18.71\u2009mm (interquartile range, IQR 35), and the tumor thickness was 6.72\u2009mm (IQR 15.50). Twelve CSCCs exhibited perineural infiltration, and eight CSCCs exhibited invasion beyond the subcutaneous fat. Positive margins after excision of the tumor in 22 aCSCCs vs eight naCSCCs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02). Nineteen poor\u2010prognosis events were observed (local recurrence, lymph node metastasis, and death from CSCC). However, no differences were observed between both groups when comparing poor\u2010prognosis events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proportion of unfavorable events is similar in aCSCC and naCSCC. The acantholytic histopathological subtype is not associated with a poorer prognosis than the non\u2010acantholytic CSCC in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14116","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T16:20:39Z","timestamp":1628353239000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case\u2010control study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-6144","authenticated-orcid":false,"given":"Alberto","family":"Conde\u2010Ferreir\u00f3s","sequence":"first","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moyano\u2010Bueno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5142","authenticated-orcid":false,"given":"\u00c1ngel","family":"Santos\u2010Briz","sequence":"additional","affiliation":[{"name":"Department of Pathology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Revelles\u2010Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Revilla\u2010Nebreda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Becerril\u2010Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Rom\u00e1n\u2010Curto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ca\u00f1ueto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"IBMCC\u2010CSIC  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/cup.12869"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1002\/1097-0142(196611)19:11<1639::AID-CNCR2820191131>3.0.CO;2-N"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1111\/j.1600-0560.1989.tb00024.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1001\/archderm.1947.01520080017002"},{"unstructured":"National Comprehensive Cancer Network. 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