{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:22:35Z","timestamp":1769721755403,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010753","name":"National Health Laboratory Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004695","name":"Inyuvesi Yakwazulu-Natali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Histoplasma capsulatum var. duboisii<\/jats:italic> (<jats:italic>H. duboisii<\/jats:italic>) causes potentially fatal disease in the immunocompromised patient, and the literature on these cases is limited. The study was undertaken to describe the cases of <jats:italic>H. duboisii<\/jats:italic> seen in a resource\u2010limited setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 5\u2010year retrospective, laboratory\u2010based histopathologic review of all <jats:italic>H. duboisii<\/jats:italic> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 patients were diagnosed with cutaneous <jats:italic>H. duboisii<\/jats:italic> infection. The male\u2010to\u2010female ratio was 1.4. All the patients were human immunodeficiency virus (HIV) positive, and 70.83% (17 of 24 patients) were on antiretroviral therapy. The clinically identified lesions were as follows: plaques, nodular plaques, papules, papulo\u2010pustules, and umbilicated papules. Histopathological appraisal revealed organisms typical of <jats:italic>H. duboisii<\/jats:italic>. The commonest epidermal alterations were interface change, parakeratosis, spongiosis, ulceration, acanthosis, hyperkeratosis, transepidermal elimination, and exocytosis in decreasing order. The dermal changes included histiocytic pattern (n\u00a0=\u00a014), neutrophil\u2010rich (n\u00a0=\u00a013), non\u2010necrotizing granulomatous inflammation (n\u00a0=\u00a09), and karyorrhexis (n\u00a0=\u00a06). Histoplasma was confirmed in 53% (8 of 15 samples) of the tissue samples submitted for routine fungal culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed the demographics, clinical and histopathology features of <jats:italic>H. duboisii<\/jats:italic> infection in a resource\u2010limited setting. Further research on histopathological features of this rare infection is essential to expand on the knowledge base and support findings in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14118","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T10:50:22Z","timestamp":1628592622000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp><i>Histoplasma capsulatum var. duboisii<\/i><\/scp>: A <scp>KwaZulu\u2010Natal<\/scp>, South Africa public sector perspective"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-6025","authenticated-orcid":false,"given":"Lerato Claudia","family":"Khathali","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology, National Health Laboratory Service &amp; School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal  Durban South Africa"},{"name":"Department of Anatomical Pathology  Mayville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamalenkosi Bonginkosi","family":"Nhlonzi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, National Health Laboratory Service &amp; School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal  Durban South Africa"},{"name":"Department of Anatomical Pathology  Mayville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-5659","authenticated-orcid":false,"given":"Absalom","family":"Mwazha","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, National Health Laboratory Service &amp; School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal  Durban South Africa"},{"name":"Department of Anatomical Pathology  Mayville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1997.tb00237"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01102915"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a067017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00275514.1953.12024317"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/3755474"},{"key":"e_1_2_11_7_1","unstructured":"South African government. South Africa's people. 2020https:\/\/www.gov.za\/about-sa\/south-africaspeople. Accessed May 18 2020."},{"key":"e_1_2_11_8_1","unstructured":"KwaZulu\u2010Natal Department of health. Health statistics available for KwaZulu\u2010Natal.http:\/\/www.kznhealth.gov.za. Accessed May 26 2020."},{"key":"e_1_2_11_9_1","unstructured":"Republic of South Africa. Stats SA. Mortality and causes of death in South Africa 2017: Findings from death notification. 2020.https:\/\/www.kznhealth.gov.za. Accessed May 26 2020."},{"key":"e_1_2_11_10_1","unstructured":"Republic of South Africa. Provincial profile KwaZulu\u2010Natal community survey 2016. 2018.https:\/\/www.statssa.gov.za. Accessed May 26 2020."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7196\/samj.2019.v109i11.13718"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13071"},{"key":"e_1_2_11_13_1","unstructured":"Genbank. NCBI.Histoplasma capsulatum var. duboisiigenes for 25S rRNA 3\u2032end ETS and 18S rRNA isolate:H88.https:\/\/www.ncbi.nlm.nih.gov\/nucore\/AB071737.1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1311.070665"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006046"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6113\/1000632"},{"key":"e_1_2_11_17_1","first-page":"1017","volume-title":"Pathology of Infectious Diseases","author":"Chandler FW","year":"1997"},{"key":"e_1_2_11_18_1","first-page":"581","volume-title":"Pathology of Tropical and Extraordinary Diseases","author":"Chapman H","year":"1976"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1984.tb01987.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.01.001"},{"key":"e_1_2_11_21_1","first-page":"595","volume-title":"Weedon's Skin Pathology","author":"Strutton G","year":"2010"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2017.07.11"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(82)80267-0"},{"key":"e_1_2_11_24_1","first-page":"881","volume-title":"McKee's Pathology of the Skin: with clinical correlations","author":"Calonje E","year":"2011"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.10.003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2411.180236"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:31:59Z","timestamp":1693200719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/cup.14118"],"URL":"https:\/\/doi.org\/10.1111\/cup.14118","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}