{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:10:59Z","timestamp":1779927059684,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA151306"],"award-info":[{"award-number":["R01 CA151306"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA200690"],"award-info":[{"award-number":["R01 CA200690"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA201376"],"award-info":[{"award-number":["R01 CA201376"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histopathologically ambiguous melanocytic lesions lead some pathologists to list multiple diagnostic considerations in the pathology report. The frequency and circumstance of multiple diagnostic considerations remain poorly characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and forty skin biopsy samples were interpreted by 187 pathologists (8976 independent diagnoses) and classified according to a diagnostic\/treatment stratification (MPATH\u2010Dx).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple diagnoses in different MPATH\u2010Dx classes were used in n\u00a0=\u00a01320 (14.7%) interpretations, with 97% of pathologists and 91% of cases having at least one such interpretation. Multiple diagnoses were more common for intermediate risk lesions and are associated with greater subjective difficulty and lower confidence. We estimate that 6% of pathology reports for melanocytic lesions in the United States contain two diagnoses of different MPATH\u2010Dx prognostic classes, and 2% of cases are given two diagnoses with significant treatment implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Difficult melanocytic diagnoses in skin may necessitate multiple diagnostic considerations; however, as patients increasingly access their health records and retrieve pathology reports (as mandated by US law), uncertainty should be expressed unambiguously.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14126","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:20:22Z","timestamp":1630941622000},"page":"153-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of multiple diagnostic terms in melanocytic skin lesion pathology reports"],"prefix":"10.1111","volume":"49","author":[{"given":"Oliver H.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L.","family":"Barnhill","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Translational Research Institut Curie, Paris Sciences and Lettres Research University, and Faculty of Medicine University of Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Piepkorn","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Washington School of Medicine  Seattle Washington USA"},{"name":"Dermatopathology Northwest  Bellevue Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, Los Angeles, David Geffen School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stevan R.","family":"Knezevich","sequence":"additional","affiliation":[{"name":"Pathology Associates  Clovis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, Los Angeles, David Geffen School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul 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