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Skin lesions found in children with MIS\u2010C are classified into four categories: morbilliform, reticulated, scarlatiniform, and urticarial lesions. Clinicopathologic characterization within these categories is limited. Thus, we present a clear example of an urticarial lesion in the context of MIS\u2010C with well\u2010documented clinicopathologic phenomena. A previously healthy 16\u2010year\u2010old female presented with 3\u2009weeks of an itchy, burning rash initially presenting on her right forearm (and lasting greater than 24\u2009hours without migration) before spreading diffusely. She also reported fever, cough, myalgias, nausea, and vomiting of 4\u2009weeks' duration. Physical examination revealed an edematous, maculopapular, nonblanching, erythematous rash covering the patient's upper extremities, abdomen, back, anterior thighs, and face. The patient tested positive for COVID\u201019. A low\u2010grade leukocytoclastic vasculitis was noted along with intraluminal fibrin and rare microthrombi in vessels of the mid to deep dermis. The patient was diagnosed with MIS\u2010C and urticarial vasculitis. She was treated with steroids and naproxen for subsequent MIS\u2010C flares. Dapsone treatment was started for the urticarial vasculitis.<\/jats:p>","DOI":"10.1111\/cup.14134","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T09:15:18Z","timestamp":1631697318000},"page":"163-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urticarial vasculitis: A potential signpost for multisystem inflammatory syndrome in children"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-2689","authenticated-orcid":false,"given":"Hailey L.","family":"Gosnell","sequence":"first","affiliation":[{"name":"Pathology and Laboratory Medicine Institute Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Grider","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Internal Medicine Virginia Tech Carilion School of Medicine, 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