{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:46Z","timestamp":1787014066375,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Primary cutaneous anaplastic large\u2010cell lymphoma (pC\u2010ALCL) is distinguished from systemic anaplastic large\u2010cell lymphoma (S\u2010ALCL) with cutaneous involvement. Although pC\u2010ALCL is a unique entity with different genetics, clinical characteristics, and prognosis, its causes are unknown. Herein, we report the case of a Chinese woman with a 4\u2010month history of a gradually enlarged ulcerative mass in her right forearm following an unidentified insect bite. Biopsy revealed an extensive infiltrate with patches of large anaplastic lymphoid cells. These cells were immunohistochemically positive for CD45, CD30, and TIA\u20101 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK\u20101.\n                    <jats:italic>DUSP22\u2010IRF4<\/jats:italic>\n                    rearrangement was detected; on the other hand,\n                    <jats:italic>TP63<\/jats:italic>\n                    rearrangement was not observed by fluorescence in situ hybridization (FISH). No Epstein\u2010Barr virus\u2010encoded small RNAs (EBERs) were detected by ISH. Rearrangement of monoclonal\n                    <jats:italic>TCR<\/jats:italic>\n                    gene was found using BIOMED\u20102 polymerase chain reaction. No abnormality was found on the subsequent positron emission tomography\u2010computed tomography (PET\u2010CT) scan. After five cycles of cyclophosphamide + doxorubicin + vincristine + prednisolone (CHOP) chemotherapy, the patient achieved complete remission. This is the first report of a unique pC\u2010ALCL with\n                    <jats:italic>DUSP22\u2010IRF4<\/jats:italic>\n                    rearrangement following an insect bite other than S\u2010ALCL involving the skin.\n                  <\/jats:p>","DOI":"10.1111\/cup.14147","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T01:05:52Z","timestamp":1633741552000},"page":"187-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Primary cutaneous anaplastic large\u2010cell lymphoma with\n                    <scp>\n                      <i>DUSP22\u2010IRF4<\/i>\n                    <\/scp>\n                    rearrangement following insect bites"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-8466","authenticated-orcid":false,"given":"Yaping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second People's Hospital of Neijiang  Neijiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2015.36.1.35"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.17023"},{"key":"e_1_2_7_6_1","first-page":"413","volume-title":"WHO Classification of 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