{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:24:13Z","timestamp":1785601453803,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesenchymal tumors harboring <jats:italic>GLI1<\/jats:italic> gene abnormalities are a rare but distinctive group of neoplasms whose clinicopathologic features are currently evolving. In particular, examples of this tumor with <jats:italic>ACTB\u2010GLI1<\/jats:italic> gene fusion, tentatively termed <jats:italic>ACTB\u2010GLI1<\/jats:italic> epithelioid mesenchymal neoplasm (EMN), show a distinctive monomorphic round\u2010to\u2010epithelioid morphology, nested to trabecular pattern of growth, and S100+\/SOX10\u2212\/SMA\u2013 immunophenotype. We report the first case of this entity arising exclusively in the skin. A 69\u2010year\u2010old man with no prior history of neoplasia presented with a 1.5\u2010cm raised lesion on the left buttock. Histopathologic examination revealed a diffuse dermal proliferation of small, monomorphic, round\u2010to\u2010ovoid cells with hyperchromatic nuclei, focally enlarged nucleoli, and minimal eosinophilic to clear\u2010staining cytoplasm. These cells were arranged in confluent nests and trabeculae in a background of fibrocollagenous to focally myxoid stroma. Immunohistochemical analysis revealed strong positivity for S100 and CD56, and negativity for SOX\u201010, SMA, Melan\u2010A, HMB\u201045, and a variety of other markers. Based on the morphology and immunophenotype, molecular studies were performed, which revealed the presence of an <jats:italic>ACTB\u2010GLI1<\/jats:italic> fusion transcript, confirming the diagnosis. Given the morphologic overlap of this tumor with other cutaneous round cell neoplasms and its potential for malignant behavior, <jats:italic>ACTB\u2010GLI1<\/jats:italic> EMN is an important entity for pathologists to recognize.<\/jats:p>","DOI":"10.1111\/cup.14152","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:46:51Z","timestamp":1634158011000},"page":"284-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Primary cutaneous epithelioid mesenchymal neoplasm with <i>ACTB\u2010GLI1<\/i> fusion: a case report"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-6248","authenticated-orcid":false,"given":"Benjamin T.","family":"Rollins","sequence":"first","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-0858","authenticated-orcid":false,"given":"David S.","family":"Cassarino","sequence":"additional","affiliation":[{"name":"Los Angeles Kaiser Permanente Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0293-x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001439"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001360"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919900548"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12366"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.68"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4730"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22916"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.07.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63723-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914567330"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000178091.54147.b1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0618-0"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:39:59Z","timestamp":1693111199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/cup.14152"],"URL":"https:\/\/doi.org\/10.1111\/cup.14152","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]},"assertion":[{"value":"2021-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}