{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:53Z","timestamp":1747184213264,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syphilis is a sexually transmitted infectious disease caused by the bacterium <jats:italic>Treponema pallidum<\/jats:italic> and can cause a wide variety of cutaneous manifestations, most commonly, a papulosquamous eruption of the trunk and extremities. Treatment with penicillin is curative. We report a case of a 69\u2010year\u2010old man who presented with recent onset of blurry vision and a nonpainful, nonpruritic eruption of pink\u2010to\u2010violaceous dermal nodules on his upper trunk and upper extremities. Biopsies of two separate locations revealed a dense superficial and deep perivascular atypical lymphocytic infiltrate with admixed plasma cells, histiocytes, and eosinophils. Some scattered cells expressed CD30, PD1, BCL\u20106, and ICOS. T\u2010cell receptor (TCR)\u2010rearrangement showed an identical TCR\u2010gamma clone between both biopsy specimens. The patient was subsequently seen by ophthalmology and diagnosed with acute anterior uveitis. Rapid plasma reagin was reactive and cerebrospinal fluid studies showed findings consistent with a diagnosis of neurosyphilis. A <jats:italic>T. pallidum<\/jats:italic> immunostain of the skin biopsies was performed upon re\u2010review, and was diffusely positive for spirochetes at the dermal\u2010epidermal junction and within injured vessels. The patient was treated with penicillin G with near\u2010resolution of his skin lesions. This case highlights the unusual ability of syphilis to mimic a T\u2010cell lymphoma with matching clones across two different biopsy sites.<\/jats:p>","DOI":"10.1111\/cup.14153","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T20:43:09Z","timestamp":1634503389000},"page":"288-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clonal cutaneous and neurosyphilis: A pitfall in pseudolymphoma diagnosis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-9578","authenticated-orcid":false,"given":"Lauren G.","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina A.","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Cropley","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology &amp; Oncology University of Virginia Cancer Center  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-8074","authenticated-orcid":false,"given":"Alejandro A.","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-1542","authenticated-orcid":false,"given":"Shyam S.","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"issue":"18","key":"e_1_2_5_2_1","first-page":"402","article-title":"Primary and secondary syphilis\u2014United States, 2005\u20102013","volume":"63","author":"Patton ME","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.073"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12518"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.062"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000144"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2018.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-391748"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408542"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-698977"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz317"},{"issue":"93","key":"e_1_2_5_13_1","first-page":"1","article-title":"Myelopathy secondary to human T\u2010lymphotropic virus and Treponema pallidum infection: case report","volume":"5","author":"Enr\u00edquez\u2010Ruano P","year":"2019","journal-title":"Spinal Cord Ser Cases"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702003000400008"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:40:03Z","timestamp":1693111203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/cup.14153"],"URL":"https:\/\/doi.org\/10.1111\/cup.14153","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"2021-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}