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Tumor\u2010associated macrophages (TAMs) mostly have M2 phenotype that promotes tumor progression. This study investigated CD68+ and CD163+ TAMs as well as CD163\/CD68 ratio in skin lesions from different stages of MF, large\u2010plaque parapsoriasis, and SS. Moreover, we analyzed serum levels of sCD163 and CCL22 in correlation with TAMs count and CD163\/CD68 ratio. CD68+ and CD163+ TAMs count significantly increased as the disease progressed. CD163\/CD68 ratio was highest at MF tumor stage and SS indicating M2 polarization with disease progression. Significant positive correlations were detected between serum levels of sCD163 and CCL22 and CD68+ and CD163+ TAMs count and CD163\/CD68 ratio. We concluded that TAMs play an important role in MF progression. High CD163\/CD68 ratio in tumor stage MF and SS indicates M2 polarization of TAMs with tumor progression. CD163\/CD68 ratio should be considered in assessing TAMs rather than total TAMs count. Also, sCD163 and CCL22 serum levels reflect M2 load and thus could be used as markers to assess disease progression.<\/jats:p>","DOI":"10.1111\/cup.14155","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T15:29:41Z","timestamp":1635002981000},"page":"261-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential role of tumor\u2010associated macrophages and <scp>CD163<\/scp>\/<scp>CD68<\/scp> ratio in mycosis fungoides and S\u00e9zary syndrome in correlation with serum <scp>sCD163<\/scp> and <scp>CCL22<\/scp>"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-0618","authenticated-orcid":false,"given":"Dina M.","family":"El\u2010Guindy","sequence":"first","affiliation":[{"name":"Pathology Department, Faculty of Medicine Tanta University  Tanta 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