{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:43:08Z","timestamp":1785894188638,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous gamma\/delta T\u2010cell lymphoma (PCDG\u2010TCL) is aggressive, frequently presenting as multiple plaques, tumors, and\/or subcutaneous nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we conducted a retrospective study in a tertiary center in Taiwan to characterize this rare tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified six patients. Five presented with a solitary lesion, including two with clinical impression of epidermal inclusion cyst or lipoma. Two of four evaluable cases exhibited epidermotropism, with one mimicking Pautrier microabscess. The neoplastic cells were pleomorphic and mostly medium\u2010 to large\u2010sized. In all cases, the neoplastic cells expressed T\u2010cell receptor (TCR)\u2010\u03b3 and\/or TCR\u2010\u03b4, with four co\u2010expressing \u03b2F1. Two of these \u03b2F1+ cases co\u2010expressed TCR\u2010\u03b3 but not TCR\u2010\u03b4 (two different clones). All were negative for Epstein\u2013Barr virus (EBV), low stage, and treated with radiotherapy alone or combined chemotherapy and radiotherapy. In two patients, lymphoma relapsed in 3 and 7\u2009months, respectively, and one patient died of the disease in 7\u2009months. Four other patients were free of disease for 6 to 126\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCGD\u2010TCL cases in Taiwan are more commonly solitary, frequently with indolent courses. The two currently available TCR\u2010\u03b4 clones alone might be insufficient to detect all tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14169","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:35:47Z","timestamp":1636958147000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary cutaneous gamma\/delta T\u2010cell lymphoma in Taiwan: A series of six cases with frequent solitary presentation and relatively indolent behavior"],"prefix":"10.1111","volume":"49","author":[{"given":"Bo\u2010Jung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology Shuang Ho Hospital, Taipei Medical University  New Taipei City Taiwan"},{"name":"Department of Pathology, School of Medicine College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren Ching","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Nursing College of Nursing, HungKuang University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Yang","family":"Jhuang","sequence":"additional","affiliation":[{"name":"Department of Pathology Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine Lioying Chi\u2010Mei Hospital  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Zhen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pathology Chi\u2010Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010En","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Chia\u2010Yi Taiwan"},{"name":"School of Medicine Tzu Chi University  Hualian Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Ta","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Chia\u2010Yi Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Chia\u2010Yi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-525X","authenticated-orcid":false,"given":"Shih\u2010Sung","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chi\u2010Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"397","volume-title":"WHO Classification of Tumours of Haemtopoietic and Lymphoid Tissues","author":"Gaulard P","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1597"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826a5038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.086637"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822067d1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13671"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.03.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP8BPFJ5JHUXLU"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"617","article-title":"Expression of the alpha\/beta and gamma\/delta T\u2010cell receptors in 57 cases of peripheral T\u2010cell lymphomas. 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