{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:22:42Z","timestamp":1782451362951,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acquired lymphangioma circumscriptum of the vulva is rare and can occur subsequent to malignancies of the anogenital and pelvic region. We sought to investigate the clinicopathologic characteristics of malignancy\u2010associated acquired vulvar lymphangioma circumscriptum (AVLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all cases of AVLC within our institution with history of prior malignancy between 2005 and 2021. A similar search was performed in the PubMed database to identify published cases to date. The clinical and histopathologic information was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 71 cases were identified. The most common preceding malignancy was cervical carcinoma (71.8%, 51\/71). Radiation therapy was given to 91.4% (64\/70) of the patients and lymph node dissection was made on 70.2% (40\/57). Median interval between the diagnosis of malignancy and the AVLC was 10\u2009years (range 0\u201032\u2009years). AVLC frequently presented as vesicular (31.6%, 18\/57) or verrucous (28.1%, 16\/57) lesions clinically. Common treatments for AVLC included excision (53.1%, 26\/49) and laser therapy (16.3%, 8\/49), with an overall recurrence rate of 42.9% (24\/56) at a median follow\u2010up interval of 1.8\u2009years (range 0.04\u201032.3\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AVLC is a rare, late complication of anogenital and pelvic malignancies causing debilitating physical symptoms and psychological stress. Further studies are warranted to determine the most effective treatment modalities to mitigate recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14181","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T07:55:33Z","timestamp":1638950133000},"page":"426-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>Malignancy\u2010associated<\/scp> acquired vulvar lymphangioma circumscriptum: A clinicopathologic study of 71 cases"],"prefix":"10.1111","volume":"49","author":[{"given":"Yen T.","family":"Luu","sequence":"first","affiliation":[{"name":"School of Medicine University of Missouri\u2013Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooks D.","family":"Kimmis","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Kansas Hospital  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared S.","family":"Bodine","sequence":"additional","affiliation":[{"name":"Kansas City University of Medicine and Biosciences  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika C.","family":"Gloyeske","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Hospital  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-9462","authenticated-orcid":false,"given":"Hongyan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Hospital  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13264"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00048-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199901000-00014"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"335","article-title":"Vulval lymphangiectasia","volume":"65","author":"Handfield\u2010Jones SE","year":"1989","journal-title":"Genitourin Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670310131027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.94293"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31829655cb"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.11.019"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"448","article-title":"Acquired lymphangiectasia (\u201clymphangioma circumscriptum\u201d) of the vulva: a report of eight cases","volume":"41","author":"Stewart CJR","year":"2009","journal-title":"Pathology (Phila)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2016.03.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01569.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200209000-00007"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"17","article-title":"Surgical management of vulvar lymphangioma circumscriptum: two case reports","volume":"36","author":"Ikeda M","year":"2011","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001398"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10158"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.79854"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3801-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(85)90052-6"},{"issue":"6","key":"e_1_2_7_21_1","first-page":"987","article-title":"Lymphangioma of vulva; 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