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This report describes for the first time the detection of a saprophytic, human oral Tenericutes species, <jats:italic>Mycoplasma faucium<\/jats:italic>, in the skin lesions of a patient presenting initially guttate and later plaque psoriasis. An unusual finding in standard histopathology investigation consisted of round and oval thinly stained or unstained, possibly intracellular structures, apparently directly pressing on keratinocyte nuclei of the psoriatic stratum spinosum. In ultrastructural study, wall\u2010less bacteria were present intracellularly in the keratinocytes, mainly of the psoriatic stratum spinosum, and extracellularly in the upper dermis of the psoriatic lesions. <jats:italic>M<\/jats:italic>. <jats:italic>faucium<\/jats:italic> was consistently detected and identified in the psoriatic skin by general Tenericutes polymerase chain reaction and sequencing in two biopsies performed 31\u00a0months apart. This case raises new questions concerning the pathogenesis of psoriasis and its accepted autoimmune\/autoinflammatory nature.<\/jats:p>","DOI":"10.1111\/cup.14182","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T08:04:50Z","timestamp":1638950690000},"page":"463-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evidence for the presence of a human saprophytic oral bacterium, <i>Mycoplasma faucium<\/i>, in the skin lesions of a psoriatic patient"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4018-8784","authenticated-orcid":false,"given":"Michael","family":"Arabatzis","sequence":"first","affiliation":[{"name":"First Department of Dermatology\u2010Venereology, Medical School Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristea","family":"Velegraki","sequence":"additional","affiliation":[{"name":"Mycology Research Laboratory and UOA\/HCPF Culture Collection, Microbiology Department, Medical School National and Kapodistrian University of Athens  Athens Greece"},{"name":"Mycology Laboratory, BIOIATRIKI S.A.  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