{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:27:20Z","timestamp":1791358040968,"version":"4.3.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extended\u2010release formulation of exenatide for treatment of Type II diabetes mellitus is encapsulated in microspheres composed of poly(<jats:sc>d,l<\/jats:sc>\u2010lactide\u2010co\u2010glycolide) (PLGA) and administered weekly. This medication has been reported to potentially cause injection\u2010site reactions such as pruritus, transient nodules, and foreign body reaction. Here, we report a case of exenatide\u2010induced granulomatous panniculitis. Our patient is a 63\u2010year\u2010old female with Type II diabetes presenting for concerns about painful nodules on her abdomen, developing approximately every week over the past year and migrating. Of note, the lesions appeared following exenatide injections in the same locations. Two deep\u2010seated nodules of 1\u2009cm were identified on examination. There were no overlying skin changes, and the lesions were tender to palpation. Punch biopsies of the two lesions were performed, which revealed a septal panniculitis containing amorphous material, along with a mixed inflammatory infiltrate. Gomori methenamine silver (GMS) and acid\u2010fast bacilli (AFB) stains were negative for organisms. On infrared (IR) spectroscopy examination of the biopsy tissue, the spectral characteristics of (tissue) protein and PLGA were seen. Evaluation of the clinical and histopathologic findings, along with the IR spectroscopy match, determined that exenatide\u2010induced panniculitis was the cause of the patient's nodules. This case highlights the importance of clinicians' awareness regarding injection\u2010site reactions.<\/jats:p>","DOI":"10.1111\/cup.14193","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T11:53:33Z","timestamp":1640519613000},"page":"496-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Exenatide\u2010induced<\/scp> granulomatous panniculitis associated with poly(<scp>d,l<\/scp>\u2010<scp>lactide\u2010co<\/scp>\u2010glycolide)"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-6031","authenticated-orcid":false,"given":"Caroline S.","family":"Zhu","sequence":"first","affiliation":[{"name":"University of Texas Health Sciences Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie A.","family":"Kwan","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium  Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant M.","family":"Williams","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium  Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lewin\u2010Smith","sequence":"additional","affiliation":[{"name":"The Joint Pathology Center  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Lincoln","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium  Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail J.","family":"Lee","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium  Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.28.4.283"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12246"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000952"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11209750-000000000-00000"},{"key":"e_1_2_6_6_1","unstructured":"Bydureon Safety Information. 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