{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:02Z","timestamp":1747184222706,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes affected individuals to persistent infection with certain types of human papillomavirus (HPV), particularly those that belong to the genus beta\u2010HPV, including HPV\u20105 and HPV\u20108, which carry high oncogenic potential. There are three main HPV\u2010related viral cytopathic changes in cutaneous verrucae in terms of intracytoplasmic inclusion bodies (ICBs), namely, granular, filamentous, and homogeneous type ICBs. To date, only HPV\u20104, HPV\u201060, and HPV\u201065 have been found in association with homogeneous ICBs. We report a unique case of HPV\u201049\u2010associated EDV in a 41\u2010year\u2010old woman with common variable immunodeficiency, mycosis fungoides, and multiple cutaneous malignancies, including squamous cell carcinoma and Merkel cell carcinoma who presented with multiple pink papules and hyperpigmented macules on the left upper extremity. One of the skin lesions histopathologically revealed keratinocytic nuclear enlargement with abundant blue\u2013gray cytoplasm, accompanied by hypergranulosis, characteristic of EDV, along with peculiar bright eosinophilic and homogeneous ICBs. To the best of our knowledge, this is the first reported case of EDV with detection of HPV\u201049 by genotyping, which features eosinophilic homogeneous ICBs, like those seen in the setting of HPV\u20104, HPV\u201060, or HPV\u201065 infection.<\/jats:p>","DOI":"10.1111\/cup.14221","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T14:23:35Z","timestamp":1646749415000},"page":"658-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eosinophilic homogeneous intracytoplasmic inclusion bodies: Unique viral cytopathic changes associated with epidermodysplasia verruciformis and human papillomavirus type 49"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-9684","authenticated-orcid":false,"given":"Brooke R.","family":"Bartley","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Texas Health Science Center at 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