{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:03Z","timestamp":1747184223020,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A new variant of endemic pemphigus foliaceus is present in El Bagre, Colombia, and surrounding municipalities (El Bagre\u2010EPF) that affects the skin and in some presentations affects other organs with autoantibodies directed against cell junctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 200 El Bagre\u2010EPF patient perilesional skin biopsies, as well as 200 skin biopsies from normal controls in the endemic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed blister extrusions of sebaceous glands or entire pilosebaceous units via the isthmus in 23% of the patients and not in the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extrusion of hair follicular unit contents is consistent with our previous pathologic findings of autoreactivity to these units, and their observed clinical decrease in patients affected by El Bagre\u2010EPF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14225","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T16:37:52Z","timestamp":1647535072000},"page":"604-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extrusion of pilosebaceous units into blisters of patients affected by a new variant of endemic pemphigus in El Bagre, Colombia, South America"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-4133","authenticated-orcid":false,"given":"Ana Maria","family":"Abreu\u2010Velez","sequence":"first","affiliation":[{"name":"Georgia Dermatopathology Associates  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-6227","authenticated-orcid":false,"given":"Yulieth Alexandra","family":"Upegui\u2010Zapata","sequence":"additional","affiliation":[{"name":"PECET, Medical Research Institute, School of Medicine, University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Andres","family":"Valencia\u2010Yepes","sequence":"additional","affiliation":[{"name":"Department of Education University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Upegui\u2010Quice\u00f1o","sequence":"additional","affiliation":[{"name":"PECET, Medical Research Institute, School of Medicine, University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-6093","authenticated-orcid":false,"given":"Michael S.","family":"Howard","sequence":"additional","affiliation":[{"name":"Georgia Dermatopathology Associates  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"51","article-title":"Endemic pemphigus foliaceus over a century: part I","volume":"2","author":"Abreu\u2010Velez AM","year":"2010","journal-title":"N Am J Med Sci"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00851-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00852-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(03)00034-3"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"359","article-title":"The tryptic cleavage product of the mature form of the bovine desmoglein 1 ectodomain is one of the antigen moieties immunoprecipitated by all sera from symptomatic patients affected by a new variant of endemic pemphigus","volume":"13","author":"Abreu\u2010Velez AM","year":"2003","journal-title":"Eur J 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