{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:53:36Z","timestamp":1791676416456,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several mutations and gene fusions involved in the mitogen\u2010activated protein kinase (MAPK) pathway have been reported in histiocytic neoplasms including Langerhans cell histiocytosis and non\u2010Langerhans\u2010cell histiocytosis (NLCH). We identified a <jats:italic>GAB2::BRAF<\/jats:italic> fusion in a cutaneous lesion from a 22\u2010year\u2010old woman who presented with central diabetes insipidus and red\/brown papules on her face, oral mucosa, axilla, and groin. Skin biopsy showed a CD68+, S100\u2212, and CD1a\u2212 histiocytic proliferation consistent with NLCH, best clinically classified as xanthoma disseminatum. Next\u2010generation sequencing identified a <jats:italic>GAB2::BRAF<\/jats:italic> fusion involving exon 2 of <jats:italic>GAB<\/jats:italic> and exon 10 of <jats:italic>BRAF<\/jats:italic>. This case implicates a novel fusion in the MAPK signaling pathway, not previously reported in histiocytic neoplasms, as a possible driver of NLCH. Our findings underscore the utility of performing molecular studies on skin biopsy specimens with NLCH to help identify potential targets for therapy.<\/jats:p>","DOI":"10.1111\/cup.14231","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T11:39:08Z","timestamp":1648208348000},"page":"727-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel <scp><i>GAB2::BRAF<\/i><\/scp> fusion in cutaneous non\u2010Langerhans\u2010cell histiocytosis with systemic involvement"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-5399","authenticated-orcid":false,"given":"Bicong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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