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We used quantitative pathology to compare the immunologic composition of anti\u2010PD\u20101\u2010associated interface reactions to LP and aGVHD to assess for similarities and differences between these cutaneous eruptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry for CD4, CD8, CD68, PD\u20101, and PD\u2010L1 was performed on formalin\u2010fixed paraffin\u2010embedded tissue from patients with anti\u2010PD\u20101 interface cirAEs (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), LP (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), or aGVHD (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). Densities of immune cell subsets expressing each marker were quantified using the HALO image analysis immune cell module. Plasma cell and eosinophil density were quantified on routine H&amp;E slides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Specimens from patients with anti\u2010PD\u20101 interface cirAEs showed equivalent total cell densities and immune cell composition to those with aGVHD. Patients with LP showed higher total immune cell infiltration, higher absolute T\u2010cell densities, increased CD8 proportion, and reduced histiocytic component. The cases with the highest plasma cell counts were all anti\u2010PD\u20101 interface cirAEs and aGVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The composition of immune cell subsets in anti\u2010PD\u20101 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14242","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T11:33:18Z","timestamp":1650540798000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immune cell subsets in interface cutaneous immune\u2010related adverse events associated with <scp>anti\u2010PD<\/scp>\u20101 therapy resemble acute graft versus host disease more than lichen planus"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-3789","authenticated-orcid":false,"given":"Guillermo E.","family":"Almodovar Cruz","sequence":"first","affiliation":[{"name":"Department of Dermatology at Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center and 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Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center and Bloomberg\u2010Kimmel Institute for Cancer Immunotherapy at Johns Hopkins  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-4395","authenticated-orcid":false,"given":"Janis M.","family":"Taube","sequence":"additional","affiliation":[{"name":"Department of Dermatology at Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center and Bloomberg\u2010Kimmel Institute for Cancer Immunotherapy at Johns Hopkins  Baltimore Maryland USA"},{"name":"Department of Pathology at Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center and Bloomberg\u2010Kimmel Institute for Cancer Immunotherapy at Johns Hopkins  Baltimore Maryland USA"},{"name":"Department of Oncology at Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center and Bloomberg\u2010Kimmel 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