{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:44Z","timestamp":1787014064569,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The status of cutaneous epithelioid angiomatous nodule (CEAN) as a distinct entity remains controversial. This study investigated the relationship between CEAN and epithelioid hemangioma\/angiolymphoid hyperplasia with eosinophilia (ALHE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of seven lesions with CEAN features from four cases (Cases 1\u20134: 61\u2010year\u2010old, 76\u2010year\u2010old, 53\u2010year\u2010old, and 21\u2010year\u2010old men, respectively) were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cases 1 and 2 showed multiple lesions in the head and neck region, but Cases 3 and 4 showed solitary lesions on the back and scalp, respectively. Moreover, the histopathologic findings of the lesions of Cases 1 and 2 were consistent with those of conventional epithelioid hemangioma or classic cutaneous ALHE. Diffuse immunoexpression of FOSB was observed in Cases 1 and 2, but\n                      <jats:italic>FOSB<\/jats:italic>\n                      split signals were absent in break\u2010apart fluorescence in situ hybridization (FISH). In contrast, the histopathologic findings of the lesions of Cases 3 and 4 were consistent with those of cellular\u2010type epithelioid hemangiomas. Diffuse immunoreactivity for c\u2010FOS was observed in Cases 3 and 4, and split signals of\n                      <jats:italic>FOS<\/jats:italic>\n                      were present in break\u2010apart FISH in Case 3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed that the seven tumors with CEAN features could be reclassified under the epithelioid hemangioma\/ALHE group, although the small sample size is a limitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.14246","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T23:39:20Z","timestamp":1651361960000},"page":"765-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory  Tokyo Japan"},{"name":"Department of Anatomic Pathology Tokyo Medical University  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto 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