{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:33:01Z","timestamp":1789237981817,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microsecretory adenocarcinoma (MSA) is a newly described salivary gland neoplasm characterized by <jats:italic>MEF2C::SS18<\/jats:italic> fusions. MSA was previously thought to occur exclusively in salivary glands. Here, we expand the spectrum of known primary sites of this tumor by describing a series of cutaneous tumors with analogous findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified four cutaneous primary tumors with histopathologic features identical to MSA of the salivary glands. These cases were evaluated by immunohistochemistry, fluorescence in situ hybridization (FISH) for <jats:italic>SS18<\/jats:italic> rearrangement and targeted RNA\u2010sequencing. We also queried a pan\u2010tumor database of advanced carcinomas for <jats:italic>MEF2C::SS18<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cases occurred in men ranging from 61 to 74\u2009years (mean, 68). They arose from the skin of the nose, chin, scalp, and external auditory canal. All included cords\/microcysts of eosinophilic cells with bland oval nuclei and bluish mucin within fibromyxoid stroma. The scalp tumor also exhibited high\u2010grade transformation (marked atypia, elevated mitotic rate, and necrosis), a feature unreported in salivary MSA. By immunohistochemistry, all cases were positive for S100. Two showed a myoepithelial component positive for p40 and smooth muscle actin or calponin. Three cases harbored <jats:italic>MEF2C::SS18<\/jats:italic> by RNA sequencing, while one with limited tissue had <jats:italic>SS18<\/jats:italic> rearrangement via FISH. Two patients had no evidence of recurrence or metastasis in limited follow\u2010up (3 and 6\u2009months). The pan\u2010tumor database query also did not identify <jats:italic>MEF2C::SS18<\/jats:italic> in any advanced cutaneous carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report expands the sites that can be involved by MSA. Similar to salivary cases, <jats:italic>MEF2C::SS18<\/jats:italic> represents a recurrent fusion in MSA of the skin. Unusual features in cutaneous cases not seen in salivary MSA include one case with high\u2010grade transformation and two cases with a myoepithelial cell component. Identification of this fusion expands the spectrum of salivary\u2010analog cutaneous tumors and aids in precise tumor classification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14271","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T17:49:47Z","timestamp":1655056187000},"page":"134-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Microsecretory adenocarcinoma of the skin harboring recurrent <i>SS18<\/i> fusions: A cutaneous analog to a newly described salivary gland tumor"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-6810","authenticated-orcid":false,"given":"Justin A.","family":"Bishop","sequence":"first","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Williams","sequence":"additional","affiliation":[{"name":"UCSF Dermatopathology &amp; Oral Pathology Service, Department of Pathology and Dermatology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gagan","sequence":"additional","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Rooper","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C. K.","family":"Jordan","sequence":"additional","affiliation":[{"name":"UCSF Dermatopathology &amp; Oral Pathology Service, Department of Pathology and Dermatology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"LeBoit","sequence":"additional","affiliation":[{"name":"UCSF Dermatopathology &amp; Oral Pathology Service, Department of Pathology and Dermatology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0157-RA"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20168"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20184"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20938"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0462-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000734"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001091"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000463"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01331-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001273"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01280-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2696"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126185"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001286"},{"key":"e_1_2_9_16_1","volume-title":"Head and Neck Tumours","author":"Bishop JA","year":"2022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12987"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCR.0000000000000076"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.032"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.065"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.14271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:54:27Z","timestamp":1692510867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/cup.14271"],"URL":"https:\/\/doi.org\/10.1111\/cup.14271","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"2022-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}