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Punch biopsy of a plaque performed to evaluate for leukemia cutis revealed a lymphocytic lobular\u2010panniculitis\u2010like infiltrate resembling lupus panniculitis, but a preponderance of CD8+\/Ki\u201067+ T\u2010cells surrounding adipocytes raised concern for subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL). Additional immunohistochemistry (IHC) studies showed that the adipotropic T\u2010cells expressed TCR\u2010gamma, supporting the rare, unexpected diagnosis of Primary cutaneous gamma\u2010delta T\u2010cell lymphoma (PCGDTCL). The patient subsequently met diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH). PCGDTCL is an aggressive, HLH\u2010associated lymphoma requiring different management than SPTCL and SLL. This case illustrates how PCGDTCL can co\u2010exist with B\u2010cell lymphoma and resemble panniculitis on biopsies. PCGDTCL and SPTCL should enter the differential diagnosis whenever patients present with the constellation of lobular panniculitis and unexplained cytopenias. In the present case, close clinicopathologic correlation and judicious use of IHC on a small sample allowed for a prompt diagnosis.<\/jats:p>","DOI":"10.1111\/cup.14293","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T09:10:00Z","timestamp":1657962600000},"page":"1015-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary cutaneous gamma\u2010delta T\u2010cell lymphoma masquerading as leukemia cutis in a patient recently diagnosed with small lymphocytic lymphoma: Clues to the diagnosis"],"prefix":"10.1111","volume":"49","author":[{"given":"Koorosh","family":"Haghayeghi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhrumil","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of 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