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The aim of this review is to evaluate the effectiveness of the most often used immunohistochemical melanocyte markers in the diagnosis of intraepidermal lesions. All the analyzed markers can be useful in detection of intraepidermal melanocytes that occur more densely in lentigo maligna than in solar lentigo or sun\u2010damaged skin. However, the number of these cells is underestimated by HMB\u201045 and Mel\u20105. The cytoplasmic Melan\u2010A staining may overestimate melanocyte number and highlight the dendritic process. Atypical melanized keratinocytes in actinic keratoses and nest\u2010like structures in lichenoid dermatoses may mimic atypical melanocytes in melanomas in situ. S\u2010100 remains a marker of high sensitivity but low specificity. The nuclear localization of MITF, SOX\u201010, and PRAME overcomes the problem of melanosome transfer to cells of other types. Neither MITF nor SOX\u201010 is detectable in keratinocytes, which makes them useful in distinguishing actinic keratoses from melanomas in situ. The use of markers considered as melanocyte specific suggests that lichenoid dermatoses constitute a heterogeneous group of lesions.<\/jats:p>","DOI":"10.1111\/cup.14295","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:34:19Z","timestamp":1658219659000},"page":"1074-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The detectability of intraepidermal melanocytes\u2014A narrative review of immunohistochemical studies"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-4465","authenticated-orcid":false,"given":"\u0141ukasz","family":"Ku\u017abicki","sequence":"first","affiliation":[{"name":"Department of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Toru\u0144  Toru\u0144 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna 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