{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:49:29Z","timestamp":1791420569607,"version":"4.3.3"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun\u2010exposed skin. Squamous cell carcinoma is a potential long\u2010term complication. The most important risk factor for squamous cell carcinoma development in people with dark skin is chronic scarring and inflammation, such as those seen in long\u2010standing discoid plaques. African Americans who develop squamous cell carcinoma in the setting of chronic scarring and inflammation have a greater risk of metastasis and recurrence compared to sun\u2010induced squamous cell carcinoma seen in whites. Despite this, the pathogenesis of squamous cell carcinoma development in chronic DLE is not fully understood. Herein, we describe a case of an African American patient who developed squamous cell carcinoma on a long\u2010standing discoid plaque. Analysis of the lesion revealed a null type pattern of p53 protein expression and abundant CD123<jats:sup>+<\/jats:sup> plasmacytoid dendritic cells, as potential drivers of oncogenesis and inflammation, respectively. Dermatologists should be aware of the increased risk of squamous cell carcinoma development within long\u2010standing discoid plaques for a prompt early diagnosis and active long\u2010term surveillance.<\/jats:p>","DOI":"10.1111\/cup.14304","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T02:19:45Z","timestamp":1659579585000},"page":"19-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-6121","authenticated-orcid":false,"given":"Teresa","family":"Ju","sequence":"first","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Miami Itch Center University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ingrasci","sequence":"additional","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Miami Itch Center University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-7314","authenticated-orcid":false,"given":"Julio A.","family":"Diaz\u2010Perez","sequence":"additional","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Miami Itch Center University of Miami  Miami Florida USA"},{"name":"Department of Dermatology University of Tennessee  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderonke","family":"Obayomi","sequence":"additional","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Miami Itch Center University of Miami  Miami Florida 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and functional analysis of tumor\u2010infiltrating plasmacytoid dendritic cells in head and neck cancer","volume":"63","author":"Hartmann E","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2001.0518"},{"issue":"4","key":"e_1_2_7_13_1","first-page":"195","article-title":"Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus","volume":"86","author":"Simpson JK","year":"2010","journal-title":"Cutis"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033753"}],"container-title":["Journal of Cutaneous 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