{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:50:32Z","timestamp":1780915832532,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>T\u2010cell\u2010rich angiomatoid polypoid pseudolymphoma (TRAPP) and inflammatory lobular hemangioma (ILH) encompass a spectrum of cutaneous vascular lesions in which a prominent lymphoplasmacytic component may impart a pattern highly reminiscent of low\u2010grade cutaneous lymphoma (pseudolymphoma). Epithelioid hemangioma, including its most common variant angiolymphoid hyperplasia with eosinophilia (ALHE), is a distinct entity associated with FOS and\/or FOSB expression detected by immunohistochemistry (IHC). These entities can show significant morphological overlap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed IHC for FOSB, FOS, and lymphoid markers in a series of TRAPP\/ILH and ALHE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 13 cases of ILH\/TRAPP, which showed a predominance in CD8<jats:sup>+<\/jats:sup> T\u2010cells (CD8&gt;CD4: 11\/13) while FOSB and FOS were expressed in 36% (4\/11) and 27% (3\/11) of cases, respectively. ALHE (<jats:italic>n<\/jats:italic>\u00a0=\u20099) showed a predominance in CD4<jats:sup>+<\/jats:sup> T\u2010cell (67%) with FOSB and FOS co\u2010expression in 78% (seven of nine) of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed, based on FOS and\/or FOSB immunohistochemical expression, that there is a possible link between ILH\/TRAPP and epithelioid hemangioma\/ALHE. The use of FOS and FOSB IHC in the routine diagnostic setting of cutaneous vascular lesions will help to redefine cases of ILH\/TRAPP as a subset of these may represent inflammatory variants of epithelioid hemangioma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14317","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T03:55:21Z","timestamp":1661486121000},"page":"1067-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inflammatory lobular hemangioma (T\u2010cell\u2010rich angiomatoid polypoid pseudolymphoma)\u2014Assessment of <scp>FOS<\/scp>\/<scp>FOSB<\/scp> and lymphoid markers and comparison with epithelioid hemangioma"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5088","authenticated-orcid":false,"given":"Ana Cristina","family":"Vargas","sequence":"first","affiliation":[{"name":"Douglass Hanly Moir Pathology Sonic Healthcare  Macquarie Park New South Wales Australia"},{"name":"Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research, Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona M.","family":"Maclean","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology Sonic Healthcare  Macquarie Park New South Wales Australia"},{"name":"Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research, Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Yee","family":"Tsu","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology Sonic Healthcare  Macquarie Park New South Wales 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