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The term EDV acanthoma may be applied to lesions with incidental findings of EDV\u2010defining histopathological features without clinical signs of EDV. We report a case of HPV\u201014\u2010 and \u201021\u2010positive EDV acanthoma arising in association with condyloma in a female patient with a history of low\u2010grade squamous intraepithelial lesion of the cervix positive for high\u2010risk HPV (non\u201016\/18), chronic kidney disease, and systemic lupus erythematosus. The patient had no family or personal history of EDV, but the patient was on immunosuppressive therapy with mycophenolate mofetil and prednisone. A biopsy specimen from one of the perianal lesions revealed histopathologic changes consistent with EDV in the setting of condyloma. Molecular testing showed HPV\u201014 and \u201021, which supported the coexistence of condyloma with EDV acanthoma.<\/jats:p>","DOI":"10.1111\/cup.14319","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T08:13:34Z","timestamp":1661847214000},"page":"47-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Condyloma and coincidental epidermodysplasia verruciformis acanthoma positive for human papillomavirus\u201014 and \u201021"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-9684","authenticated-orcid":false,"given":"Brooke","family":"Bartley","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-1403","authenticated-orcid":false,"given":"Woo 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