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However, dermatologic toxicities associated with non\u2212immune checkpoint inhibitor (non\u2010ICI) mAbs may complicate the course of cancer treatment. Data on the incidence and types of these reactions are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive review was conducted on dermatologic toxicities associated with different classes of non\u2010ICI mAbs approved for treatment of solid tumors and hematologic malignancies. The review included prospective Phase 1, 2, and 3 clinical trials; retrospective literature reviews; systematic reviews\/meta\u2010analyses; and case series\/reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermatologic toxicities were associated with several types of non\u2010ICI mAbs. Inflammatory reactions were the most common dermatologic toxicities, manifesting as maculopapular, urticarial, papulopustular\/acneiform, and lichenoid\/interface cutaneous adverse events (cAEs) with non\u2010ICI mAbs. Immunobullous reactions were rare and a subset of non\u2010ICI mAbs were associated with the development of vitiligo cAEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dermatologic toxicities of non\u2010ICI mAbs are diverse and mostly limited to inflammatory reactions. Awareness of the spectrum of the histopathologic patterns of cAE from non\u2010ICI mAbs therapy is critical in the era of oncodermatology and oncodermatopathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14327","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T12:15:40Z","timestamp":1662552940000},"page":"72-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The diverse landscape of dermatologic toxicities of non\u2010immune checkpoint inhibitor monoclonal antibody\u2010based cancer therapy"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-8350","authenticated-orcid":false,"given":"Riyad N. 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