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Basosquamous carcinoma (BSC) is an aggressive type of basal cell carcinoma (BCC) characterized by squamous differentiation. Herein, we report a case of metastatic BSC that developed in a 73\u2010year\u2010old male with NS. The clinical presentation of this patient was that of an ulcerative nodule developing in a longstanding plaque\u2010like lesion consistent with NS. Histopathological examination revealed characteristic features of BCC with some areas of squamous differentiation in addition to the structure of a typical NS. Immunohistochemical expression of Ber\u2010EP4, AE1\/AE3, and epithelial membrane antigen helped to make the diagnosis of BSC.<\/jats:p>","DOI":"10.1111\/cup.14332","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T07:17:19Z","timestamp":1663831039000},"page":"306-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastasis of a basosquamous carcinoma arising in a nevus sebaceus"],"prefix":"10.1111","volume":"50","author":[{"given":"Qian","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Burn Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing 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