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Of them, most are found in patients diagnosed with tuberous sclerosis complex (TSC). FCCH has distinctive histopathologic features, including collagen deposition in the dermis, perifollicular fibrosis, and comedones with keratin\u2010containing cysts lined by infundibular epithelium. We report three patients with a definitive TSC clinical diagnosis in whom clinical, histopathologic, and molecular features were studied to establish if there exists a genotype\u2013phenotype correlation. The molecular results showed different heterozygous pathogenic variants (PV) in <jats:italic>TSC2<\/jats:italic> in each patient: NM_000548.4:c.5024C&gt;T, NG_005895.1:c.1599+1G&gt;T, and NM_000548.4:c.2297_2298dup, to our knowledge; the latter PV has not been reported in public databases. The same PVs were identified as heterozygous in the tumor tissue samples, none of which yielded evidence of a <jats:italic>TSC2<\/jats:italic> second hit. Because all FCCH patients with available molecular diagnosis carry a pathogenic genotype in <jats:italic>TSC1<\/jats:italic> or <jats:italic>TSC2<\/jats:italic>, we suggest that FCCH should be considered as a new and uncommon diagnostic manifestation in the TSC consensus international diagnostic criteria. The early recognition of FCCH by clinicians could prompt the identification of new TSC cases. Interestingly, our molecular findings suggest that one of the patients described herein is a probable case of somatic mosaicism.<\/jats:p>","DOI":"10.1111\/cup.14340","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T05:20:11Z","timestamp":1665724811000},"page":"481-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical, pathological, and molecular correlation of folliculocystic and collagen hamartoma: A new potential diagnostic criterion for tuberous sclerosis complex?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-1430","authenticated-orcid":false,"given":"David","family":"Apam\u2010Gardu\u00f1o","sequence":"first","affiliation":[{"name":"Servicio de Gen\u00e9tica Hospital General de M\u00e9xico  Mexico City 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