{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:43Z","timestamp":1787014063499,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mesenchymal neoplasms with\n                    <jats:italic>GLI1<\/jats:italic>\n                    alterations (rearrangements and\/or amplification) have been reported recently in several anatomic locations, which include head and neck, soft tissue, and gastrointestinal tract. Herein, to the best of our knowledge, we describe the first three cases of superficial\/subcutaneous mesenchymal neoplasm with\n                    <jats:italic>GLI1<\/jats:italic>\n                    amplification. The neoplasms exhibited low\u2010grade cytologic features with predominant round cell morphology, glomangioma\u2010like areas and a rich background capillary network. There were two to three mitotic figures per 10 HPF and focal necrosis in one case. The tumors exhibited variable expression of CDK4, MDM2, STAT6, D2\u201040, CD56 and cyclin D1. p16 had strong and diffuse nuclear and cytoplasmic expression in two cases. Numerous other stains were negative. Fluorescence in situ hybridization detected\n                    <jats:italic>GLI1<\/jats:italic>\n                    ,\n                    <jats:italic>DDIT3<\/jats:italic>\n                    , and\n                    <jats:italic>CDK4<\/jats:italic>\n                    coamplification in all cases, while next generation sequencing did not detect a\n                    <jats:italic>GLI1<\/jats:italic>\n                    gene fusion. The overall features were compatible with a\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010amplified mesenchymal neoplasm. In Case 1 a new distant skin lesion appeared 1\u2009month after the surgery exhibiting similar morphology albeit with a higher mitotic index. In Cases 2 and 3, there is no evidence of local recurrence or systemic disease after 8\u2009years and 1\u00a0month of follow\u2010up, respectively. These new cases of superficial\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010amplified neoplasm expand its clinical spectrum and enter the realm of dermatopathology. The combination of CDK4, cyclin D1, D2\u201040, and p16 expression with variable MDM2, STAT6, CD56, and S100 immunoreactivity in a low\u2010grade neoplasm with round\/ovoid cytomorphology resembling a vascular or adnexal neoplasm may suggest the possibility of\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010amplified neoplasm.\n                  <\/jats:p>","DOI":"10.1111\/cup.14345","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T23:06:56Z","timestamp":1667257616000},"page":"487-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Superficial\n                    <i>GLI1<\/i>\n                    \u2010amplified mesenchymal neoplasms: Expanding the spectrum of an emerging entity which reaches the realm of dermatopathology"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-1330","authenticated-orcid":false,"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"},{"name":"Pathology Department Patologika Laboratory, Hospital QuironSalud  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-0565","authenticated-orcid":false,"given":"Gregory A.","family":"Hosler","sequence":"additional","affiliation":[{"name":"Dermatopathology ProPath  Dallas Texas USA"},{"name":"Department of Dermatology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Traves","sequence":"additional","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zazo","sequence":"additional","affiliation":[{"name":"Pathology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-3507","authenticated-orcid":false,"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Dermatology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente Sanchis","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Hospital Arnau de Vilanova  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Villaverde","family":"Domenech","sequence":"additional","affiliation":[{"name":"Plastic Surgery Service University Hospital Castellon  Castellon 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