{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:49:11Z","timestamp":1692593351549},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Facial skin is characterized by high density of follicles. Facial neoplasms may present overlapping clinical and dermoscopic findings. Our goal was to evaluate and compare, via reflectance confocal microscopy (RCM), follicular involvement in facial neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively searched our image database, between January 2008 and December 2020, for all facial lesions with (1) a standardized set of clinical, dermoscopic, and RCM images, and (2) a biopsy\u2010proven diagnosis of lentigo maligna\/lentigo maligna melanoma (LM\/LMM, <jats:italic>n<\/jats:italic>\u00a0=\u200939), basal cell carcinoma (BCC, <jats:italic>n<\/jats:italic>\u00a0=\u200951), squamous cell carcinoma in situ (SCCIS, <jats:italic>n<\/jats:italic>\u00a0=\u20095), actinic keratosis (AK, <jats:italic>n<\/jats:italic>\u00a0=\u200911), and lichen\u2010planus\u2010like keratosis (LPLK, <jats:italic>n<\/jats:italic>\u00a0=\u200918). Two readers jointly evaluated the RCM images for a set of predefined features of follicular involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diffuse obliteration of follicles was frequent in BCC (88%), while follicular infiltration by refractile dendritic cells and\/or by bright round nucleated cells was common in melanoma (90% and 44%, respectively). Extension of atypical keratinocytes down follicles was more prominent among SCCIS than AK (80% vs. 45%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.01). In most LPLK (89%), there was follicular sparing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evaluation of RCM criteria centering on the follicles can be useful in the differential diagnosis between common facial neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14353","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T10:29:33Z","timestamp":1667384973000},"page":"178-184","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reflectance confocal microscopy of facial neoplasms: Follicular involvement as a clue to diagnosis"],"prefix":"10.1111","volume":"50","author":[{"given":"Neda","family":"Shahriari","sequence":"first","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"Grant\u2010Kels","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut USA"},{"name":"Department of Dermatology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Rabinovitz","sequence":"additional","affiliation":[{"name":"Skin and Cancer Associates  Plantation Florida USA"},{"name":"Dermatology Department Medical College of Georgia at Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Oliviero","sequence":"additional","affiliation":[{"name":"Skin and Cancer Associates  Plantation Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Scope","sequence":"additional","affiliation":[{"name":"The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Dermatology Service Memorial Sloan Kettering Center  New York New York 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