{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:17:17Z","timestamp":1770909437122,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel class of superficial CD34<jats:sup>+<\/jats:sup> and S100<jats:sup>+<\/jats:sup> cutaneous spindle cell neoplasm harboring <jats:italic>ALK<\/jats:italic> rearrangements has recently been described. Morphologically, these neoplasms have been characterized by bland spindled cells organized in whorls and cords against myxoid stroma, eventuating in the designation \u201csuperficial <jats:italic>ALK<\/jats:italic>\u2010rearranged myxoid spindle cell neoplasm.\u201d Here, we report a 78\u2010year\u2010old male with a 3\u2010mm pink papule on the chest, clinically concerning for cutaneous carcinoma. Biopsy of the specimen showed a biphasic tumor with hypercellular and hypocellular zones consisting of epithelioid cells and monomorphic, bland spindled cells. The spindled cells were arranged in perineurial\u2010like concentric whorls and cords embedded in a myxo\u2010collagenous stroma. Neoplastic cells were diffusely positive for CD34, S100, and D5F3\u2010ALK, without SOX10 expression. Negative markers included GLUT1, EMA, factor XIIIa, desmin, actin, and SMA. <jats:italic>ALK\u2010<\/jats:italic>rearrangement was identified on fluorescence in situ hybridization break\u2010apart assay. A corresponding novel <jats:italic>FMR1\u2010ALK<\/jats:italic> fusion was found by next\u2010generation sequencing (NGS) based RNA sequencing. Identification of this new <jats:italic>FMR1\u2010ALK<\/jats:italic> fusion signature adds to the spectrum of diagnostic genomic alterations in this newly described class of tumors.<\/jats:p>","DOI":"10.1111\/cup.14354","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T08:46:11Z","timestamp":1667465171000},"page":"505-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A novel case of cutaneous myxoid spindle cell neoplasm with <scp><i>FMR1\u2010ALK<\/i><\/scp> gene fusion and <scp>CD34<\/scp>\/<scp>S100<\/scp> co\u2010expression"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-288X","authenticated-orcid":false,"given":"Israel","family":"Kasago","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Aypar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purvil","family":"Sukhadia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Vanderbilt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ladanyi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tierra","family":"Hurd","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9186","authenticated-orcid":false,"given":"Melissa","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York 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