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This tumor is histopathologically similar to lipofibromatosis, but unlike lipofibromatosis shows reactivity for S100 and has an <jats:italic>NTRK\u20101<\/jats:italic> kinase fusion. These lesions are locally aggressive but appear to have a negligible metastatic potential. Subsequently, a more cellular variant has been described with generally low mitotic rate. This variant also displays S100 reactivity and kinase fusions (typically involving <jats:italic>NTRK\u20101<\/jats:italic>), but it has a low risk of metastasis. In this report, we describe a case that aligns with the more cellular variant of <jats:italic>NTRK\u20101<\/jats:italic> kinase fusion tumors on histopathologic, immunohistochemical, and molecular grounds, but in addition has distinctive nodules with peripheral accentuation of cellularity, reminiscent of those present in epithelioid malignant peripheral nerve sheath tumors. This latter feature is previously undescribed in <jats:italic>NTRK<\/jats:italic> kinase fusion soft tissue tumors and offers further support for the presumed neural differentiation of this neoplasm.<\/jats:p>","DOI":"10.1111\/cup.14355","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T15:19:48Z","timestamp":1667747988000},"page":"343-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An <scp>NTRK<\/scp>\u20101\u2010associated soft tissue tumor showing distinctive nodules with peripheral accentuation of cellularity"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-3852","authenticated-orcid":false,"given":"Rebecca","family":"Czaja","sequence":"first","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla 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