{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:25:52Z","timestamp":1750098352091,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus is a group of immunobullous dermatoses characterized by the presence of autoantibodies directed against adhesion molecules of keratinocytes, with pemphigus vegetans being the rarest form, accounting for 1%\u20132% of all cases of pemphigus. Pemphigus vegetans is characterized by verrucous vegetative lesions in addition to vesiculobullous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a rare case of pemphigus vegetans presenting as an isolated vegetative lesion in the groin 3\u2009months prior to the development of blisters. Owing to the atypical presentation, multiple biopsies were performed before and after corticosteroid treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing the histopathology of pre\u2010treatment and post\u2010treatment biopsy specimens, the resolution of intraepidermal microabscesses, and reduction in intraepidermal and dermal inflammatory infiltrates, spongiosis and interface change, attributable to treatment, were noted. However, direct immunofluorescence showed persistent intracellular intraepidermal deposition of IgG and C3 2\u2009weeks into treatment, despite near\u2010complete resolution of blisters on clinical examination. Clinical regression of the vegetative lesion was noted only after 6\u2009weeks into corticosteroid treatment, while histopathological evidence of treatment was apparent at the second week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current case illustrates the importance of a liberal use of immunofluorescence studies in establishing the uncommon yet significant diagnosis of pemphigus vegetans, particularly for vegetative lesions that are persistent, in the intertriginous areas and\/or in the setting of concurrent cutaneous or mucosal symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14375","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T15:33:51Z","timestamp":1670772831000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare presentation of pemphigus vegetans as an isolated vegetative lesion\u2014Review of histopathological clues and treatment effects in multiple biopsy specimens"],"prefix":"10.1111","volume":"50","author":[{"given":"Joanna Ka Man","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Man\u2010Tung","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Faculty of Medicine, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Cheung Lung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edric Chi\u2010Ching","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Faculty of Medicine, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0314","authenticated-orcid":false,"given":"Joshua Jing Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes Wai Sze","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Faculty of Medicine, Prince of Wales Hospital The Chinese University of Hong Kong  Hong 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the right foot: case report","volume":"122","author":"Ma DL","year":"2009","journal-title":"Chin Med J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468919"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.123511"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.011"}],"container-title":["Journal of Cutaneous 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